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. 2024 Jun 4;22(6):e3002641. doi: 10.1371/journal.pbio.3002641

Fig 4. miR-505-5p target genes related to FA sensing are down-regulated after treatment with miR-505-5p in vitro and in fetal hypothalamus of offspring from obese mothers.

Fig 4

(a) Relative mRNA expression of genes related to lipid metabolism in mHypoE-N46 cells after treatment with a miR-505-5p mimic and (b) in the hypothalamus of fetuses from control or obese pregnancy at E13 * P < 0.05, ** P < 0.01, *** P < 0.001. Statistical significance was determined by unpaired T test. Outliers were excluded from (a) for miR-505-5p mimic (Cpt1a outlier excluded value 1.19, Soat1 outlier excluded value 1.71). The underlying data are provided as S1 Data file. FA, fatty acid.