Table 1. Main sociodemographic and clinical characteristics of the study population.
| Main characteristics | Controls (n = 104) | Cases (n = 117) | p value |
|---|---|---|---|
| Age (years) | 37.00 [6.00] | 43.00 [9.00] | < 0.001 |
| BMI* (kg/m 2 ) | 23.72 [5.58] | 23.80 [5.76] | 0.234 |
| Underweight (<18,5) | 4 (3.85) | 5 (4.27) | NA |
| Normal weight (18,5–24,9) | 61 (58.65) | 62 (52.99) | NA |
| Overweight(25–29,9) | 29 (27.88) | 29 (24.79) | NA |
| Obesity (>30) | 10 (9.62) | 21 (17.95) | NA |
| Pathology | |||
| No hormone-dependent pathology | 104 (100.00) | - | |
| Leiomyomas | - | 74 (63.25) | |
| Endometriosis | - | 21 (17.95) | |
| Leiomyomas and endometriosis | - | 22 (18.80) | |
| Hormonal contraception (HC) | |||
| Ever users of HC | 60 (57.69) | 62 (53.45) | 0.527 |
| Oral contraceptives | 51 (49.04) | 57 (50.00) | 0.887 |
| Transdermal patch | 4 (3.85) | 3 (2.63) | 0.712 |
| Vaginal ring | 13 (12.50) | 6 (5.26) | 0.058 |
| LNG releasing IUD | 3 (2.88) | 10 (8.77) | 0.067 |
| Contraceptive implant | 2 (1.92) | 2 (1.75) | 1.000 |
| Time of HC use (years) | 6.00 [7.00] | 5.00 [7.75] | 0,737 |
| Parity | |||
| Number of children | 2 [1.00] | 1 [2.00] | < 0,001 |
| Nuliparous | 3 (2.88) | 51 (43.97) | < 0,001 |
| Age at first childbirth (years) | 33.00 [6.00] | 30.0 [9.00] | 0,004 |
| Postmenopausal | 2 (1.92) | 6 (5.17) | 0,286 |
| Current smokers | |||
| Yes | 5 (4.81) | 18 (15.52) | 0,010 |
| Years of smoking habit | 10.80 [10.03] | 22.50 [9.91] | 0,043 |
| Number of cigarretes/day | 10.00 [9.00] | 10.00 [9.75] | 0,880 |
| No | |||
| Former smokers | 47 (45.19) | 41 (35.34) | 0,137 |
| Years since termination | 3.00 [7.00] | 9.50 [11.75] | <0,001 |
| Never smokers | 52 (50.00) | 57 (49.14) | 0,898 |