Fig. 4.

Investigation of immune profiles. A Estimation of immune infiltrations using six methods (TIMER, CIBERSORT, quanTIseq, MCP-counter, xCell, and EPIC). B ssGSEA results revealing differences in immune cell abundances C-G Immune landscapes between the two subtypes: C immune checkpoints, D genomic heterogeneity indices (TBM, MSI, HRD and LOH), E stemness indices (DNAss, RNAss, DMPss and ENHss), F scores derived from the ESTIMATE algorithm (immune score, stromal score, and estimate score) and G immune-related pathways. Significance levels are denoted by the following symbols: *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001