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. 2024 Jun 5;14:12874. doi: 10.1038/s41598-024-62828-z

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Protein network analysis of representative inflammatory signaling-related genes downregulated by ESS. We performed protein network analysis using genes associated with the Toll-like receptor signaling pathway, TNF signaling pathway, and NF-kappa B signaling pathway that were downregulated by ESS. (a) Toll-like receptor signaling pathway (genes 1 to 15: Tlr1, Tlr3, Tlr7, Ifnb1, Irf7, Tlr8, Nfkb1, Tnf, Ccl3, Ccl4, Ccl5, Cd40, Cd80, Cxcl10, Ikbke), TNF signaling pathway (genes 16 to 37: Lta, Map3k8, Tnfrsf1b, Traf1, Pik3r2, Pik3r3, Nfkbia, Cflar, Ccl2, Cxcl1, Cxcl2, Cxcl3, Fas, Il15, Lif, Socs3, Tnfaip3, Ifi47, Junb, Edn1, Icam1, Ptgs2), NF-kappa B signaling pathway (genes 38 to 46: Edaradd, Blnk, Trim25, Malt1, Bcl2l1, Bcl2a1a, Bcl2a1b, Bcl2a1d, Gadd45a). (b) Analysis of the correlation between genes associated with co-expression.