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Improvement effect of skin conditions in DNCB-induced HR-1 mice by ESS. DNCB-induced HR-1 mice were topically treated with various concentrations of ESS (100, 500 ppm) (n = 7/group). On the final day of the experiment, (a) the skin conditions of HR-1 mice were observed and (b) body weight was measured. The values presented are the mean ± SEM obtained from at least seven independent experiments. Statistical significance is indicated as follows: ***p < 0.001, **p < 0.01, and *p < 0.05.
