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. 2024 Jun 5;14:12874. doi: 10.1038/s41598-024-62828-z

Figure 9.

Figure 9

Improvement of skin histology and serum IgE by ESS treatment in DNCB-induced HR-1 mice. In DNCB-induced HR-1 mice, we observed histopathological features of the skin that were altered by ESS treatment. Changes in epidermal thickness of the back skin induced by atopic dermatitis-like symptoms were observed with (a, c) H&E staining (n = 12 pictures per group), and changes in dermal infiltration of mast cells were observed with (b, d) Toluidine Blue staining (n = 20 pictures per group). (e) The effect of ESS treatment on serum IgE levels in HR-1 mice with atopic dermatitis-like symptoms DNCB-induced (n = 7 per group). The values presented are the mean ± SEM from independent experiments. Statistical significance is indicated as follows: ***p < 0.001, **p < 0.01, and *p < 0.05. Scale bar = 100 μm.