TABLE 2.
Summary of relevant pharmacokinetic parameters for the nicotine containing study products and mean extraction rate of nicotine from pouches.
| Product | Cmax (ng/mL) | tmax (min) | AUC0–240min (ng/mL × h) | t1/2 (h) | Nicotine extraction (%) |
|---|---|---|---|---|---|
| 6 mg nicotine pouch | 2.8 (39%) | 20 (5–36) | 4.9 (65%) | 2.4 (1.2) | 38% |
| 20 mg nicotine pouch | 7.1 (72%) | 15 (5–60) | 11.6 (77%) | 2.2 (1.5) | 24% |
| 30 mg nicotine pouch | 29.4 (58%) | 15 (5–30) | 45.7 (60%) | 1.8 (0.6) | 52% |
| Tobacco cigarette | 15.2 (111%) | 5 (2–15) | 22.1 (59%) | 2.3 (1.4) | — |
Cmax and AUC: Geometric mean and coefficient of variation (CV%); tmax: Median and range; t1/2: arithmetic mean and standard deviation.