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. 2024 May 22;18:1305867. doi: 10.3389/fncel.2024.1305867

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Copyright © 2024 Lin, Gong, Wu, Lin, Zhang, Lin, Huang and Zhu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The ketogenic diet regulates the cAMP signaling pathway and influences epileptic seizure. (A) Behavioral observation in mice (Racine score), n = 10, * indicates difference between the KD + RMI 12330A group and the KD group (p < 0.05). (B) Analysis of mouse EEG, and vertical arrows indicate the beginning and end of seizures in mice. (C) Frequency of epileptic epilepsy, n = 10, * indicates difference between the KD + RMI 12330A group and the KD group (p < 0.05). (D,E) Levels of β-hydroxybutyrate and Glucose, n = 10, * indicates difference between the KD + RMI 12330A group and the KD group (p < 0.05). (F) Western Blot analysis of ADCY3, CREB, pCREB, cAMP, and PKA expression levels in mice, n = 6, * indicates difference between the KD + RMI 12330A group and the KD group (p < 0.05), ns indicates no difference between the KD + RMI 12330A group and the KD group (p > 0.05). (G) Detection of sIPSC using electrophysiological techniques, bar graph (right) represents frequency and amplitude, scale bar, 100 ms and 1,000 pA, n = 20 neurons. (H) Detection of eIPSC using electrophysiological techniques, bar graph (right) represents amplitude, scale bar, 2 s and 20 pA, n = 20 neurons. (I) Measurement of the relative intensity in calcium ion concentrations among the different groups of mice’s neurons using calcium imaging techniques (scale bar = 25 μm), n = 10 cells, * indicates difference between the KD + RMI 12330A group and the KD group (p < 0.05).