Table 25. Diagnostic Criteria for Familial type III hyperlipidemia.

Main items	(1) Serum cholesterol and serum triglyceride levels are both elevated
	(2) Electrophoresis of plasma lipoproteins shows a broad β pattern of continuity from VLDL to LDL
	(3) Electrophoresis of apolipoproteins to prove abnormalities of apolipoprotein E (E2/E2, E deficiency, etc.)
Sub items	(1) Xanthoma (especially palmar linear xanthoma)
	(2) Increased serum apolipoprotein E concentration (apolipoprotein E/total cholesterol ratio ＞0.05)
	(3) VLDL cholesterol/serum TG ratio greater than 0.25
	(4) Decrease in LDL cholesterol
	(5) With ASCVD such as arteriosclerosis obliterans and ischemic heart disease
Diagnosis	Definite diagnosis when all three major items are present.
	Diagnosis as suspected when 2 of the major items and 1 or more of the sub items are present

(Translated and reprinted from the Ministry of Health and Welfare, Research Group for the Investigation of Primary Hyperlipidemia of Specific Diseases, FY 1986 and 1987 Report)