TABLE 2.
Incidence of Late-Onset Sepsis Pathogen Types by Study Year and Gestational Age Category
| Category | N | All Late-Onset Sepsisa (No., %) | Incidence Rate Per 1000 Eligible Infantsa (99% CI) | CONSb (No., %) | GBSb (No., %) | Other GPb (No., %) | GNb (No., %) | Fungalb (No., %) |
|---|---|---|---|---|---|---|---|---|
| Overall | 118 650 | 10 501 (8.9) | 88.5 (86.4–90.7) | 3549 (3.0) | 569 (0.5) | 3436 (2.9) | 3692 (3.1) | 620 (0.5) |
| Study year | ||||||||
| 2018 | 40 295 | 3514 (8.7) | 87.2 (83.7–90.9) | 1224 (3.0) | 196 (0.5) | 1153 (2.9) | 1228 (3.1) | 213 (0.5) |
| 2019 | 40 727 | 3609 (8.9) | 88.6 (85.1–92.3) | 1193 (2.9) | 203 (0.5) | 1182 (2.9) | 1261 (3.1) | 201 (0.5) |
| 2020 | 37 628 | 3378 (9.0) | 89.8 (86.0–93.6) | 1132 (3.0) | 170 (0.5) | 1101 (2.9) | 1203 (3.2) | 206 (0.6) |
| GA category, completed wkc | ||||||||
| ≤23 | 5708 | 1838 (32.2) | 322.0 (306.3–338.1) | 611 (10.7) | 68 (1.2) | 516 (9.0) | 766 (13.4) | 224 (3.9) |
| 24–25 | 16 781 | 3669 (21.9) | 218.6 (210.5–227.0) | 1270 (7.6) | 149 (0.9) | 1235 (7.4) | 1330 (7.9) | 229 (1.4) |
| 26–27 | 23 368 | 2583 (11.1) | 110.5 (105.4–115.9) | 889 (3.8) | 159 (0.7) | 865 (3.7) | 838 (3.6) | 104 (0.5) |
| 28–29 | 32 590 | 1579 (4.9) | 48.5 (45.5–51.6) | 509 (1.6) | 124 (0.4) | 507 (1.6) | 530 (1.6) | 44 (0.1) |
| >29 | 40 199 | 832 (2.1) | 20.7 (18.8–22.6) | 270 (0.7) | 69 (0.2) | 313 (0.8) | 228 (0.6) | 19 (0.1) |
GN, gram-negative; GP, gram-positive.
Infants with >1 pathogen identified were counted once. There were 9067 infants with 1 pathogen identified (7.6% of total and 86.3% of infants with infection), 1270 infants with 2 pathogens identified (1.1% of total and 12.1% of infants with infection), and 164 infants with 3 or more pathogens identified (0.14% of total and 1.6% of infants with infection). Infants with >1 pathogen identified had polymicrobial infection and/or multiple distinct, late-onset sepsis episodes.
Infants with >1 pathogen identified were counted separately in each relevant group.
Four infants with missing GA were not included in the GA-specific counts.