Table 2.

Combined effects of covariates (p value and 95% CI) of complex level 1 variance models with Var(t) = 0 using 30-year truncated data

Variables	Effect estimate (95% CI)	p value
Female (onset)	0.47 (−0.10, 1.0)	0.11
Female (year 15)	−0.43 (−0.68, −0.18)	0.001
Age of onset, one SD increase (onset)	0.07 (−0.19, 0.33)	0.60
Age of onset, one SD increase (year 15)	0.73 (0.62, 0.85)	<0.001
Comparing 1986–2006 to other year-categories
Year of diagnosis (2007–2011) (onset)	−0.64 (−1.41, 0.14)	0.11
Year of diagnosis (>2011) (onset)	−0.40 (−1.04, 0.25)	0.23
Year of diagnosis (2007–2011) (year 10)	−0.45 (−0.75, −0.14)	0.004
Year of diagnosis (>2011) (year 10)	−0.90 (−1.15, −0.65)	<0.001

We compared the effect of variables on EDSS at onset and 15 years post onset for sex and age of onset, 10 years post onset for year of diagnosis, using their associations with intercept and time interactions.

CI, confidence interval; SD, standard deviation.