Table 2.
Antibody levels were obtained from maternal sera (before and after vaccination) and infant cord blood sera at birth
| Study number | Pooled SMD (95% CI) | Effect model | I 2 (%) | p value | |
|---|---|---|---|---|---|
| Maternal immunogenicity | |||||
| Before vaccination | |||||
| Nab-A | 3 | −0.30 (−0.78 to 0.19) | Random | 81 | 0.23 |
| Nab-B | 3 | 0.00 (−0.38 to 0.38) | Random | 71 | 0.99 |
| F-IgG | 3 | −0.32 (−0.91 to 0.22) | Random | 90 | 0.21 |
| At delivery (after vaccination) | |||||
| Nab-A | 4 | 3.40 (1.35–5.45) | Random | 99 | 0.001 |
| Nab-B | 4 | 1.67 (0.26–3.08) | Random | 99 | 0.02 |
| F-IgG | 3 | 7.48 (3.13–11.83) | Random | 99 | 0.0008 |
| PCA | 2 | 1.79 (1.72–1.08) | Fixed | 0 | <0.00001 |
| Infant immunogenicity | |||||
| Nab-A | 4 | 2.67 (1.12–4.22) | Random | 99 | 0.0007 |
| Nab-B | 4 | 1.22 (0.26–2.18) | Random | 98 | 0.01 |
| F-IgG | 3 | 1.49 (1.42–1.56) | Fixed | 0 | <0.00001 |
| PCA | 2 | 1.65 (1.57–1.73) | Fixed | 0 | <0.00001 |