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A structural model of retinoid receptors in gene regulation. A) structural modules of RAR and RXR. B) Residues that directly interact with atRA in RARs and 9-cis RA in RXRs are well conserved among isotypes within the family. C) Structure of atRA, 9-cis RA and docosahexaenoic acid (DHA, 22:6 omega-3). D) Transcription activation of target genes by RAR/RXR.
