. Author manuscript; available in PMC: 2024 Jun 5.

Published in final edited form as: Biochim Biophys Acta Mol Basis Dis. 2021 Jan 24;1867(5):166085. doi: 10.1016/j.bbadis.2021.166085

Table 4.

RAR/RXR target genes involved in liver fibrosis.

Target gene	Regulation	Function	Species	Cell type	References
AP-1 (RAR/RXR)	Repression	The transcription factor for regulating expression of collagenase, stromelysin, TGF-β1 and TNF-α. promoting fibrogenesis.	Rat	HSC	[80]
MLC-2 (RAR/RXR)	Repression	The sarcomeric protein for increasing HSC contractility (the RAR-β/MLC-2 axis)	Human	HSC	[81]
MLC-2 (RAR/RXR)	Repression		Mice	HSC	[81]
Col1a2 (RAR/ RXR)	Repression	A protein for the major component of extracellular matrix	Rat	HSC	[91]