Table 1.
Characteristics of Studies Included in the Meta-Analysis of CXCL12 rs1801157 Polymorphism and Breast Cancer
| First author | Country (Ethnicity) |
SOC | Genotyping methods |
Case/ Control |
Cases | Controls | HWE | MAF | ||||||||
| Genotype | Allele | Genotype | Allele | |||||||||||||
| GG | AG | AA | G | A | GG | AG | AA | G | A | |||||||
| Zafiropoulos 2004 | Greece(Caucasian) | HB | PCR-RFLP | 264/212 | 98 | 136 | 30 | 332 | 196 | 101 | 92 | 19 | 294 | 130 | 0.764 | 0.307 |
| Razmkhah 2005 | Iran(Asian) | HB | PCR-RFLP | 278/181 | 105 | 139 | 34 | 349 | 207 | 101 | 67 | 13 | 269 | 93 | 0.681 | 0.257 |
| Lin 2009 | China(Asian) | HB | PCR-RFLP | 220/334 | 106 | 98 | 16 | 310 | 130 | 175 | 136 | 23 | 486 | 182 | 0.62 | 0.272 |
| de oliverira 2009 | Brazil(mixed) | HB | PCR-RFLP | 103/97 | 59 | 41 | 3 | 159 | 47 | 61 | 32 | 4 | 154 | 40 | 0.938 | 0.206 |
| Kruszyna 2010 | Poland(Caucasian) | PB | PCR-RFLP | 193/199 | 123 | 61 | 9 | 307 | 79 | 136 | 58 | 5 | 330 | 68 | 0.685 | 0.171 |
| de oliverira 2011 | Brazil (mixed) | HB | PCR-RFLP | 55/54 | 32 | 21 | 2 | 85 | 25 | 37 | 15 | 2 | 89 | 19 | 0.757 | 0.176 |
| Kontogianni 2013 | Greece (Caucasian) | HB | PCR-RFLP | 261/480 | 114 | 118 | 29 | 346 | 176 | 247 | 198 | 35 | 692 | 268 | 0.584 | 0.279 |
| Khalid 2017 | Pakistan (Asian) | HB | PCR-RFLP | 218/147 | 138 | 59 | 21 | 335 | 101 | 47 | 86 | 14 | 180 | 114 | 0.004 | 0.388 |
| Guembarovski 2018 | Brazil (mixed) | PB | PCR-RFLP | 59/150 | 37 | 19 | 3 | 93 | 25 | 109 | 38 | 3 | 256 | 44 | 0.882 | 0.147 |
| Lin 2022 | China(Asian) | NS | Mass ARRAY |
442/448 | 259 | 167 | 16 | 685 | 199 | 293 | 134 | 21 | 720 | 176 | 0.266 | 0.196 |
SOC, source of controls; HB, hospital based; PB, population based; NS, Not stated; PCR-RFLP, restriction fragment length polymorphism; HWE, Hardy-Weinberg equilibrium; MAF: minor allele frequency