Table 1.
Physicochemical Properties of THC, CBD, and THCV
| Molecule | Fraction Csp3a,b |
No. H-bond acceptors a,b |
No. H-bond donors a,b |
MR a,b | TPSA (0Å2) a,b |
Molecular Weight (MW) |
|---|---|---|---|---|---|---|
| THC | 0.62 | 2 | 1 | 97.91 | 29.46 | 314.46 |
| CBD | 0.52 | 2 | 2 | 99.85 | 40.46 | 314.46 |
| THCV | 0.58 | 2 | 1 | 88.3 | 29.46 | 286.41 |
Fraction Csp3: ratio of sp3 hybridized carbons over the total carbon count of the molecule, H-bond: hydrogen bond, MR: molecular refractivity, TPSA: topological polar surface area bOptimal range: HBA ≤ 10, HBD ≤ 5, MR ≤ 130 TPSA ≤150 Å2