Table 10.

In silico Prediction of Cytotoxic Effect of THC, CBD, and THCV Compounds on Cancer Cell Lines

THC
Cancer cell line
Paa	Pib	Cell-line	Cell-line full name	Tissue	Tumor type
0.341	0.048	U-251	Glioma	Brain	Glioma
0.321	0.034	MKN-7	Gastric carcinoma	Stomach	Carcinoma
0.319	0.064	HOP-18	Non-small cell lung carcinoma	Lung	Carcinoma
0.344	0.096	A2058	Melanoma	Skin	Melanoma
0.389	0.155	DMS-114	Lung carcinoma	Lung	Carcinoma
Non-tumor cell line
0.328	0.048	WI-38 VA13	Embryonic lung fibroblast	Lung
0.246	0.008	PrEC	Prostate epithelial cell	Prostate
0.217	0.11	MRC5	Embryonic lung fibroblast	Lung
0.1	0.035	HaCaT	Keratinocyte	Skin
0.143	0.099	IMR-90	Embryonic lung fibroblast	Lung
CBD
Cancer-cell line
Paa	Pib	Cell-line	Cell-line full name	Tissue	Tumor type
0.542	0.004	MDA-MB-453	Breast adenocarcinoma	Breast	Adenocarcinoma
0.372	0.021	8505C	Thyroid gland undifferentiated (anaplastic) carcinoma	Thyroid	Carcinoma
0.385	0.056	NALM-6	Adult B acute lymphoblastic leukemia	Haematopoietic and lymphoid tissue	Leukemia
0.418	0.107	DMS-114	Lung carcinoma	Lung	Carcinoma
0.308	0.042	MKN-7	Gastric carcinoma	Stomach	Carcinoma
Non-tumor cell line
0.252	0.072	WI-38-VA13	Embryonic lung fibroblast	Lung
0.144	0.076	PrEC	Prostate epithelial cell	Prostate
0.099	0.036	HaCaT	Keratinocyte	Skin
THCV
Cancer cell line
Paa	Pib	Cell-line	Cell-line full name	Tissue	Tumor type
0.369	0.04	HOP-18	Non-small cell lung carcinoma	Lung	Carcinoma
0.317	0.058	U-251	Glioma	Brain	Glioma
0.318	0.059	M19-MEL	Melanoma	Skin	Melanoma
0.276	0.07	MKN-7	Gastric carcinoma	Stomach	Carcinoma
0.234	0.034	BGC-823	Stomach adenocarcinoma	Stomach	Carcinoma
Non-tumor cell line
0.364	0.041	WI-38 VA13	Embryonic lung fibroblast	Lung
0.258	0.005	PrEC	Prostate epithelial cell	Prostate
0.262	0.076	MRC5	Embryonic lung fibroblast	Lung
0.095	0.038	HaCaT	Keratinocyte	Skin

^aPa, probable activity; ^bPi, probable inactivity