Table 11.
Direct and Mediated Protein Targets of THC, CBD, and THCV
| THC | ||
|---|---|---|
| Direct Interaction | ||
| Target Name | Confidence | ChEMBL ID |
| Cannabinoid CB2 receptor | 0.4686 | (CHEMBL253) |
| Cannabinoid CB1 receptor | 0.4431 | (CHEMBL218) |
| Cytochrome P450 2C9 | 0.3556 | (CHEMBL 3397) |
| Topoisomerase II-α, | 0.3056 | (CHEMBL1806) |
| Estrogen receptor-β | 0.1988 | (CHEMBL242) |
| Mediated Interaction | ||
| Glycine receptor subunit α-1 | 0.5569 | (CHEMBL5845) |
| Cannabinoid CB2 receptor | 0.5351 | (CHEMBL253) |
| Cannabinoid CB1 receptor | 0.3306 | (CHEMBL218) |
| Serotonin 1e (5-HT1e) receptor | 0.2906 | (CHEMBL2182) |
| Nuclear receptor subfamily o group B member 1 | 0.2284 | (CHEMBL1795094) |
| CBD | ||
| Direct Interaction | ||
| Target Name | Confidence | ChEMBL ID |
| Phosphatidylinoitol-4-phosphate-5-kinasetype 1γ | 0.7681 | (CHEMBL1908383) |
| Cannabinoid CB1 receptor | 0.6356 | (CHEMBL218) |
| Serine/Threonine-protein kinase 32A | 0.6151 | (CHEMBL6150) |
| Rhodopsin kinase | 0.5937 | (CHEMBL5607) |
| Cannabinoid CB2 receptor | 0.5239 | (CHEMBL253) |
| Mediated Interaction | ||
| Cannabinoid CB2 receptor | 0.7529 | (CHEMBL253) |
| Glycine receptor subunit α-1 | 0.6822 | (CHEMBL218) |
| Tyrosine-protein kinase FYN | 0.4922 | (CHEMBL3397) |
| Cannabinoid CB1 receptor | 0.4637 | (CHEMBL218) |
| N-arachidonyl glycine receptor | 0.4088 | (CHEMBL2384898) |
| THCV | ||
| Direction Interaction | ||
| Target Name | Confidence | ChEMBL ID |
| Phosphatidylinoitol-4-phosphate-5kinasetype 1γ | 0.8084 | (CHEMBL1908383) |
| Rhodopsin kinase | 0.6532 | (CHEMBL5607) |
| Serine/Threonine-protein kinase 32A | 0.6438 | (CHEMBL6150) |
| Cannabinoid CB1 receptor | 0.6241 | (CHEMBL218) |
| Tyrosine-protein kinase Srms | 0.5934 | (CHEMBL5703) |
| Mediated Interaction | ||
| Glycine receptor subunit α-1 | 0.6769 | (CHEMBL218) |
| Cannabinoid CB2 receptor | 0.6167 | (CHEMBL253) |
| Tyrosine-protein kinase FYN | 0.4396 | (CHEMBL3397) |
| Cannabinoid CB1 receptor | 0.4253 | (CHEMBL218) |
| N-arachidonyl glycine receptor | 0.3361 | (CHEMBL218) |