Table 3.
Water Solubility Characteristics of THC, CBD, and THCV
| Molecule | ESOL | Ali | SILICOS- IT | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Log S (ESOL)b | Solubility | Classa | Log S (Ali)c | Solubility | Class a | Log S (SILICOS- IT)d |
Solubility | Class a | ||||
| mg/ml | mol/mL | mg/mL | mol/mL | mg/mL | mol/mL | |||||||
| THC | -6.11 | 2.44E-04 | 7.77E-07 | PS | -7.4 | 1.24E-05 | 3.96E-08 | PS | -5.93 | 3.96E-04 | 1.17E-06 | MS |
| CBD | -5.69 | 6.36E-04 | 2.02E-07 | MS | -7.17 | 2.14E-05 | 6.81E-08 | PS | -5.41 | 1.21E-04 | 3.86E-06 | MS |
| THCV | -5.41 | 1.12E-03 | 3.93E-06 | MS | -6.28 | 1.50E-04 | 5.23E-07 | PS | -5.13 | 2.10E-03 | 7.35E-06 | MS |
aSolubility class, PS- Poorly soluble, S- Soluble, MS- Moderately soluble, VS- Very soluble; bESOL model Log S scale, insoluble ≤ -10, poorly soluble ≤ -6, moderately soluble ≤ -4, soluble ≤ -2, very soluble ≤ 0; cAli model Log S scale, insoluble ≤ -10, poorly soluble ≤ -6, moderately soluble ≤ -4, soluble ≤ -2, very soluble ≤ 0; dSILICOS-IT model Log S scale, insoluble ≤ -10, poorly soluble ≤ -6, moderately soluble ≤ -4, soluble ≤ -2, very soluble ≤ 0