Table 5.

Medicinal Chemistry Properties of THC, CBD, and THCV

Molecule	PAINS	Brenka	Leadlikenessb	Synthetic Accessibilityc
THC	0	1 alert: isolated alkene	No; 1 violation: XLOGP3>3.5	4.27
CBD	0	1 alert: isolated alkene	No; 1 violation: XLOGP3>3.5	4.05
THCV	0	1 alert: isolated alkene	No; 1 violation: XLOGP3>3.5	4.05

^aBrenk model restrictions, ClogP/ClogD 0 to 4, HBD and HBA < 4 to 7, no. of heavy atoms 10 to 27, no. of rotatable bonds < 8, ring system < 5, no ring systems with fused rings > 2; ^bLeadlikeness considerations, MW 100 to 350 Da, ClogP 1 to 3.0; ^cSA scores, range from 1 (very easy to synthesize) to 10 (difficult to synthesize)