Table 6.
Pharmacokinetic Profile and Toxicity Prediction of THC, CBD, and THCV
| Parameter | THC | CBD | THCV |
|---|---|---|---|
| Absorption (A) | |||
| Water solubility (log mol/L) | -6.275 | -4.901 | -5.506 |
| Caco-2 permeability (log Papp, cm/s) | 1.519 | 1.79 | 1.52 |
| Intestinal absorption (human) % | 93.091 | 90.657 | 93.772 |
| Skin permeability (log Kp) | -2.538 | -2.795 | -2.441 |
| BioS (from SwissADME) | 0.55 | 0.55 | 0.55 |
| Distribution (D) | |||
| VDss (human) (log L/kg) | 0.977 | 0.939 | 0.888 |
| BBB permeability (log BB) | 0.448 | -0.113 | 0.32 |
| BBB perm. (SwissADME) | Yes | Yes | Yes |
| Metabolism (M) | |||
| CYP1A2 inhibitor | No | No | No |
| CYP2C19 inhibitor | Yes | Yes | Yes |
| CYP2C9 inhibitor | Yes | Yes | Yes |
| CYP2D6 inhibitor | Yes | Yes | Yes |
| CYP3A4 inhibitor | No | Yes | No |
| Excretion (E) | |||
| Total clearance | 0.883 | 1.092 | 0.827 |
| Renal OCT2 substrate | No | No | No |
| Toxicity (T) | |||
| Ames test | No | No | No |
| Hepatotoxicity | No | No | No |
| Oral rat acute toxicity (LD50, in mg/kg) | 482 | 500 | 482 |