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. 2024;25(3):839–856. doi: 10.31557/APJCP.2024.25.3.839

Table 8.

Rat Acute Toxicity Prediction of THC, CBD, and THCV by GUSAR

THC  CBD  THCV 
Rat IP LD50 Log10 (mmol/kg)  0,038 in AD  0,038 in AD  0,154 in AD 
Rat IV LD50 Log10 (mmol/kg)  -0,912 in AD  -0,912 in AD  -0,841 in AD 
Rat Oral LD50 Log10 (mmol/kg)  0,405 in AD  0,405 in AD  0,365 in AD 
Rat SC LD50 Log10 (mmol/kg)  -0,256 in AD  -0,256 in AD  -0,681 out of AD 
Rat IP LD50 (mg/kg)  343,300 in AD  343,300 in AD  408,100 in AD 
Rat IV LD50 (mg/kg)  38,530 in AD  38,350 in AD  41,350 in AD 
Rat Oral LD50 (mg/kg)  799,200 in AD  799,200 in AD  663,300 in AD 
Rat SC LD50 (mg/kg)  174,500 in AD  174, 500 in AD  59,660 out of AD 
Rat IP LD50 Classification  Class 4 in AD  Class 4 in AD  Class 4 in AD 
Rat IV LD50 Classification  Class 3 in AD  Class 3 in AD  Class 4 in AD 
Rat Oral LD50 Classification  Class 4 in AD  Class 4 in AD  Class 4 in AD 
Rat SC LD50 Classification  Class 4 in AD  Class 4 in AD  Class 3 out of AD