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. Author manuscript; available in PMC: 2024 Jun 5.
Published in final edited form as: Cell. 2022 Feb 3;185(3):419–446. doi: 10.1016/j.cell.2021.12.016

Figure 5. Adipocyte Progenitors and their Contribution to Adipose Tissue Homeostasis.

Figure 5.

(A) Adipocyte progenitors are specialized according to their degree of commitment to the adipocyte lineage. A consensus has emerged that the major contributors to the adipocyte lineage are adventitial fibroblasts sharing a common set of fibroblastic markers including Pdgfra and Cd34. These fibroblasts can produce both white and beige adipocytes (which can interconvert in response to environmental temperature).(B) Adipocyte progenitor cells make critical cell fate decisions including whether to differentiate or adopt a more pro-fibrogenic state. Several lines of evidence suggest that, at a tissue level, there is competition between fibrosis and adipogenesis, with key mediators acting on adipocyte progenitors to alter their cell fate decisions.