Table 2.

Comparison of SARA and ICARS Scores Progression Between SCA3-SP and SCA3-NSP Subgroups by Longitudinal Follow-Up Data

Characteristics	SARA score			ICARS score
	Coefficient	95% CI	p Value	Coefficient	95% CI	p Value
Rate difference, ya	0.918	0.4848 to 1.3508	<0.001	2.096	1.0044 to 3.1866	<0.001
Baseline age, y	0.150	0.0368 to 0.2628	0.010	0.374	0.1008 to 0.6473	0.008
Sex (male)	1.228	−0.5592 to 3.0158	0.177	2.902	−1.4154 to 7.2194	0.186
Baseline duration, y	0.519	0.2919 to 0.7454	<0.001	1.296	0.7483 to 1.8432	<0.001
Expanded CAG repeats	0.365	0.0519 to 0.6783	0.023	0.757	0.0006 to 1.5132	0.0498
Duration at visit, y	1.218	1.0108 to 1.4250	<0.001	3.480	2.9585 to 4.0024	<0.001

Abbreviations: CAG = cytosine-adenine-guanine; ICARS = International Cooperative Ataxia Rating Scale; SARA = Scale for the Assessment and Rating of Ataxia; SCA3 = spinocerebellar ataxias type 3; SCA3-SP = SCA3 patients with spastic paraplegia; SCA3-NSP = SCA3 patients with nonspastic paraplegia.

^aThe difference in rate of change in SARA and ICARS scores in the respective models between SCA3-SP and SCA3-NSP, which is the predictor of concern in this model.