TABLE 1.

CTCAE (version 5.0) grading of immunotherapy hepatotoxicity

	Grade 1	Grade 2	Grade 3	Grade 4	Grade 5
Serum AST/ ALT	1–3 × ULN (abn baseline)	> 3–5 × ULN (abn baseline)	> 5–20 × ULN (abn baseline)	> 20 × ULN (abn baseline)	Death
Alkaline phosphatase	2.5 × ULN (abn baseline)	> 2.5–5 × ULN (abn baseline)	> 5–20 × ULN (abn baseline)	> 20 × ULN (abn baseline)	Death
Total bilirubin	1–1.5 × ULN (abn baseline)	> 1.5–3 × ULN (abn baseline)	3–10 × ULN (abn baseline)	> 10 × ULN (abn baseline)	Death

Abbreviations: abn, abnormal; ALT, alanine aminotransferase; AST, aspartate aminotransferase; CTCAE, common terminology criteria for adverse events; ULN, upper limit of normal.