Table 3.

Binding energies of the top 5 CR-HDW compounds to Munich-related core targets

	Core gene docking score(kcal/mol)
Molecule name	GAPDH	AKT1	EGFR	STAT3	HSP90AA1
Core components
Quercetin	−4.04	−5.09	−4.71	−3.39	−4.70
2-methoxy-3-methyl-9,10-anthraquinone	−6.39	−7.68	−5.94	−5.68	−5.48
Bisdemethoxycurcumin	−3.96	−4.94	−4.98	−2.92	−4.38
3-epioleanic acid	−4.68	−6.73	−4.32	−3.77	−7.46
Hederagenin	−6.22	7.90	−7.44	−6.79	−6.40

AKT1, Akt murine thymoma viral oncogene homologue 1; CR-HDW, Curcumae Rhizoma and Hedyotis diffusa Willd; EGFR, epidermal growth factor receptor; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; HSP90AA1, heat shot protein 90 AA1; STAT3, signal transducer and activator of transcription 3.