Extended Data Table 1.

Sequencing data

SampleID	chrom	pos	Mut	sums	freq.(%)	genes	transcript length	ANN
CCRH_5	chr9	21538165	C>T	175	100	Ldlr	4627	T-stop_gained
CCRH_8	chr9	21536769	T>A	188	100	Ldlr	4627	A-stop_gained
CCRH_10	chr9	2544230	T>A	144	100	Ldlr	4627	A-missense_variant

Deep exon sequencing identified three distinct single point mutations in the Ldlr gene in three resistant clones (5, 8, 10) resulting in stop codons or a missense mutation.