FIG. 4.

SA11 rotavirus association with α2-K562 and α4-K562 cells 1 h p.i. and replication in these cells are significantly and specifically reduced by function-blocking MAbs to the α2 and α4 integrin subunits, respectively, whereas virus association with and replication in K562 cells are not affected by these MAbs. Prior to virus infection, K562 and α2-K562 cells were treated with anti-α2 MAb AK7 or control MAb MOPC 21 (A) and K562 and α4-K562 cells were treated with anti-α4 MAb P4C2 or control MAb ST-3:1 (B). Results shown are representative of three experiments.