FIG. 1.
Sequence features of the E1DBD. (A) Kyte-Doolittle hydropathy plot of the BPV E1121–311 protein. There are three major hydrophilic peaks, designated HR1, HR2, and HR3. HR1 and HR3 are conserved among papillomavirus E1 proteins, and HR2 is nonconserved. Mutations previously shown to impair E1 DNA binding (39) are marked with asterisks. Numbered vertical arrows indicate the amino acid number of lysine residues mutated to alanine in this study. (B) Amino acid conservation and the relative hydrophilicity of the flanking sequence regions for each lysine analyzed.