Table 3.
Pregnancy and cumulative outcomes of the CC cotreatment group and GnRHa group after propensity score matching.
| Characteristic | CC cotreatment group | GnRHa group | p value | Risk ratio (95% CI) |
|---|---|---|---|---|
| Patients, n | 375 | 375 | – | |
| Total no. of patients who underwent embryo transfer | 321 | 336 | – | |
| Total no. of embryos transferred | 579 | 821 | – | – |
| Total no. of transfer cycles | 445 | 565 | – | – |
| Cycle type of embryo transfer, n (%) | ||||
| Fresh embryo transfer | – | 217 | – | |
| Frozen embryo transfer | 445 | 348 | – | |
| Stage of embryo transferred, n (%) | ||||
| Day 3 embryo transfer | 23 (3.97) | 376 (45.80) | < 0.001 | 0.05 (0.03–0.08) |
| Blastocyst transfer | 556 (96.03) | 445 (54.20) | ||
| No. of embryos transferred, n (%) | ||||
| 1 | 311 (69.89) | 309 (54.69) | < 0.001 | 1.92 (1.48–2.50) |
| 2 | 134 (30.11) | 256 (45.31) | ||
| Implantation rate, %(n) | 45.42 (263/579) | 39.46 (324/821) | 0.028 | 1.27 (10.3–1.58) |
| Clinical pregnancy rate per transfer cycle, %(n) | 52.36 (233/445) | 46.02 (260/565) | 0.045 | 1.29 (1.01–1.65) |
| Multiple birth rate, %(n) | 17.17 (40/233) | 16.92 (44/260) | 0.943 | 1.02 (0.64–1.63) |
| Miscarriage rate, %(n) | 29.61 (69/233) | 33.85 (88/260) | 0.314 | 0.82 (0.56–1.20) |
| Ectopic pregnancy rate, %(n) | 0.43 (1/233) | 0.77 (2/260) | 1.000 | 0.56 (0.05–6.17) |
| Cumulative biochemical pregnancy rate per initial cycle, %(n) | 60.00 (225/375) | 68.80 (258/375) | 0.015 | 0.68 (0.50–0.92) |
| Cumulative clinical pregnancy rate per initial cycle, %(n) | 51.73 (194/375) | 60.27 (226/375) | 0.019 | 0.71 (0.53–0.94) |
| CLBR per initial cycle, %(n) | 41.07 (154/375) | 45.33 (170/375) | 0.238 | 0.84 (0.63–1.12) |
| Preterm birth rate, %(n) | 8.44 (13/154) | 14.71 (25/170) | 0.080 | 0.54 (0.26–1.09) |
| Average birth weight | 3300 (2973, 3550) | 3280 (2650, 3600) | 0.143 | – |
| Average gestational age at birth | 38 (38, 39) | 38 (37, 39) | 0.005 | – |
| Congenital malformation rates | 0 | 0 | 1.000 | – |
| TTLB | 360 (315.8, 445) | 326.5 (257.5, 436) | < 0.001 | – |
Data are presented as the median (25th and 75th percentile) or number (%). Mann‒Whitney U tests were used for continuous variables, and chi-square tests were used for categorical variables.
CC cotreatment clomiphene citrate and gonadotropin cotreatment, GnRHa gonadotropin-releasing hormone agonist, CI confidence interval, CLBR cumulative live birth rate, TTLB time to first live birth.