Table 1.
The research progress of SARS-CoV-2 nucleocapsid protein vaccine.
| Vaccine name | Vaccine type | N-protein usage | Animal or human experiment | References |
|---|---|---|---|---|
| Ad5-N | Viral Vectored Vaccine | Full length N-protein from SARS-CoV-2 ancestral virus, with co-expression of S protein. | Mouse | (Dangi et al., 2021) |
| MVA/SdFCS-N | Viral Vectored Vaccine | Full length N-protein from SARS-CoV-2 ancestral virus, with co-expression of S protein. | Rhesus macaque, Mouse | (Routhu et al., 2022) |
| rACAM2000SN | Viral Vectored Vaccine | Full length N-protein from SARS-CoV-2 ancestral virus, with co-expression of S protein. | Hamster | (Deschambault et al., 2022) |
| rLVSΔ capB/SCoV2 MN | LVSΔcapB Vectored Vaccine | Full length N-protein from SARS-CoV-2 ancestral virus, with co-expression of M protein. | Hamsters and mice | (Jia et al., 2021) |
| GX-19N | Recombinant DNA vaccine | Full length N-protein from SARS-CoV-2 ancestral virus, with co-expression of S protein. | healthy adult | (Ahn et al., 2022) |
| UB-612 | Multitope subunit vaccine | Rationally designed promiscuous peptides representing sarbecovirus conserved CD4 ad CD8 T cell epitopes on N, M, and S2 proteins, and S1-RBD-sFc protein.++ | healthy adult | (Wang et al., 2022) |
| RBD-P2/N | Recombinant Protein Vaccine | Full length N-protein from SARS-CoV-2 ancestral virus, with the receptor binding domain (RBD) of the spike protein fused with the tetanus toxoid epitope P2 | Mouse, Rat, NHP | (Hong et al., 2021) |
| Tri: ChAd | Viral Vectored Vaccine | Full length N-protein from SARS-CoV-2 ancestral virus, in fusion witha highly conserved region of RNA-dependent RNA polymerase and with co-expression of S1 domain of S protein. | Mouse | (Afkhami et al., 2022) |
| COH04S1 | Viral Vectored Vaccine | Full length N-protein from SARS-CoV-2 ancestral virus, with co-expression of S protein. | Hamster, NHP | (Chiuppesi et al., 2022a) |
| mRNA-S + N | RNA vaccine | A mRNA vaccine expressing fulll length N-protein from SARS-CoV-2 ancestral virus, alone or in combination withthe clinically proven S-expressing mRNA vaccine. | Mouse, Hamster | (Hajnik et al., 2022) |
| SpiN | Recombinant Protein Vaccine | Full length N-protein from SARS-CoV-2 ancestral virus, in fusion with RBD of S protein. | Mouse, Hamster | (Castro et al., 2022) |