Figure 5.

miR-146a-FLS-Exos improve behavior and inhibit apoptosis of OA chondrocytes in vivo. (A) Overview of the timeline of miR-146a-FLS-Exos treatment of OA. A rat model of OA was established using the modified Hulth method. The miR-146a-NC-FLS-Exos and miR-146a-FLS-Exos were injected into the injured joint from weeks 4–8 after surgery. The model and control groups without exosome treatment were used for comparison. The function of miR-146a-FLS-Exos in knee injuries of OA rats was evaluated using multiple assays. (B) The behavioral improvement of rats was evaluated using the Lequesne index. (C, D) Apoptosis in AC was analyzed using TUNEL staining and the proportion of apoptotic cells was assessed (×40). Data are expressed as the mean ± SEM (n = 3). **** p < 0.00001, *** p < 0.0001, ** p < 0.01, * p < 0.05.