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miR-146a-FLS-Exos induced polarization of synovial macrophages from M1 to M2. (A) Immunofluorescent co-localization of F4/80 and iNOS-positive macrophages in the rat synovium (×40). (B) Immunofluorescence co-localization of F4/80 and CD206-positive macrophage proportions in the rat synovium (×40). Data are expressed as the mean ± SEM (n = 3). **** p < 0.00001, *** p < 0.0001, ** p < 0.01.
