TABLE 1.

Summary of FDA-approved S1PR modulators.

Drug name	Brand name	Multiple sclerosis population	Approval year
Fingolimod	Gilenya	RRMS/PPMS	2010
Siponimod	Mayzent	SPMS	2019
Ozanimod	Zeposia	RRMS	2020
Ponesimod	Ponvory	RRMS	2021

Abbreviations: FDA, US, food and drug administration; S1PR, sphingosine-1-phosphat receptor.