Table 1.
Baseline characteristics of patients.
| All (N=11) |
ICI-containing treatment group (n=6) |
ICI-non-containing treatment group (n=5) | p-value† | ||
|---|---|---|---|---|---|
| Median age, years (range)* | 48 (29-66) | 50 (29-66) | 48 (23-66) | 0.783 | |
| Gender, n (%) | Male Female |
6 (54.5) 5 (45.5) |
4 (66.7) 2 (33.3) |
2 (40.0) 3 (60.0) |
0.782 |
| ECOG PS, n (%)* | 0/1 ≥ 2 |
9 (81.8) 2 (18.2) |
6 (100) 0 (0) |
3 (60.0) 2 (40.0) |
0.354 |
| Modified Kadish, n (%)** | A/B/C D |
6 (54.5) 5 (45.5) |
4 (66.7) 2 (33.3) |
2 (40.0) 3 (60.0) |
0.782 |
| Hyams’ Grade, n (%) | I/II III/IV Unknown |
6 (54.5) 3 (27.2) 2 (18.2) |
4 (66.7) 2 (33.3) 0 (0) |
2 (40.0) 1 (20.0) 2 (40.0) |
0.231 |
| Initial curative therapy, n (%) | Surgery alone Surgery followed by RT CRT alone IC followed by RT IC followed by CRT None |
3 (27.2) 1 (9.1) 1 (9.1) 1 (9.1) 4 (36.4) 1 (9.1) |
2 (33.3) 0 (0) 1 (16.7) 0 (0) 3 (50.0) 0 (0) |
1 (20.0) 1 (20.0) 0 (0) 1 (20.0) 1 (20.0) 1 (20.0) |
0.382 |
| Salvage surgery for locoregional lesion with curative intent before initiating systemic therapy | Yes No |
2 (18.2) 9 (81.8) |
2 (33.3) 4 (66.6) |
0 (0) 5 (100) |
0.182 |
|
Time from initial diagnosis to
initiation of systemic therapy, n (%) |
< 1 year ≥ 1 year |
5 (45.5) 6 (54.5) |
3 (50.0) 3 (50.0) |
2 (40.0) 3 (60.0) |
1 |
|
Local recurrence or
distant metastasis * |
Local recurrence alone Distant metastasis alone Both |
7 (63.6) 2 (18.2) 2 (18.2) |
5 (83.3) 0 (0) 1 (16.7) |
2 (40.0) 2 (40.0) 1 (20.0) |
0.164 |
*At recurrence or metastatic disease, **At initial diagnosis. †The t-test was used for continuous variables and the chi-squared test for categorical variables. ECOG PS, Eastern Cooperative Oncology Group Performance Status Scale; RT, radiotherapy; CRT, chemoradiotherapy; IC, induction-chemotherapy; and ICI, immune checkpoint inhibitor.