Figure 5.

(A) Boxplots of SUMO1P3/miR-320a levels ratio in a subgroup of urine samples from bladder cancer patients and controls, included in the validation cohort (n = 4 T0G0, n = 4 NMIBC low-grade, n = 5 NMIBC high-grade, and n = 10 MIBC). The ANOVA test with the Tukey HSD post-hoc analysis was used to determine significant differences between groups (**p-value <0.01, *p-value <0.05). (B) Receiver Operating Characteristic (ROC) curves for SUMO1P3/miR-320a levels ratio in low-grade NMBIC vs high-grade NMIBC samples (red), low-grade NMBIC vs MIBC samples (violet), and low-grade NMBIC vs high-grade NMIBC and MIBC samples pooled together (black). The corresponding ROC-AUCs are reported on the graph. The gray rectangle highlights the area in which the specificity of the test is >90%.