Figure 2.

Comparison of first and second MYC gain ($t_1$ and $t_2$) in BRCA and OV cancers using available timing methods and mutation types. Point shapes indicate whether the timed gain was clonal or subclonal, and colour indicates the number of mutations used. Vertical bars represent the 95% confidence intervals provided by cancerTiming and MutationTimeR, whereas horizontal bars represent the 95% confidence intervals provided by AmplificationTimeR. “All mutations” represents timing estimates derived using all unfiltered mutations, “C > T at CpG” represents timing estimates calculated using only C > T mutations at CpG sites, and “SBS1 and SBS5” represents timing estimates generated using only mutations identified as belonging to mutational signatures SBS1 and SBS5. (A) First MYC gain in BRCA samples. (B) Second MYC gain in BRCA samples. (C) First MYC gain in OV samples. (D) Second MYC gain in OV samples.