Table 2. Unadjusted Outcomes of Patients Receiving Antibiotics Before and After the 330-Minute Inflection Point.
| Outcome | Patients, No. (%) | P valuea | ||
|---|---|---|---|---|
| Total (N = 19 515) | Antibiotic <330 min (n = 19 164) | Antibiotic ≥330 min (n = 351) | ||
| 3-d Sepsis-attributable mortality | 97 (0.5) | 93 (0.5) | 4 (1.2) | .08 |
| 30-d Sepsis-attributable mortality | 170 (0.9) | 163 (0.9) | 7 (2.0) | .02 |
| ICU admission | ||||
| No | 10 603 (56.2) | 10 410 (56.2) | 193 (57.3) | .70 |
| Yes | 8255 (43.8) | 8111 (43.8) | 144 (42.7) | |
| Not reported | 657 (3.4) | 643 (3.4) | 14 (4.0) | |
| ICU-free days among ICU-admitted patients, median (IQR) | 26 (22-28) | 26 (22-28) | 26 (22-28) | .10 |
| Ventilator use | ||||
| No | 12 002 (80.3) | 11 783 (80.3) | 219 (81.7) | .55 |
| Yes | 2948 (19.7) | 2899 (19.7) | 49 (18.3) | |
| Not reported | 4565 (23.4) | 4482 (23.4) | 83 (23.6) | |
| Ventilator-free days among ICU-admitted patients, median (IQR) | 26 (20-28) | 26 (20-28) | 24 (0-28) | .18 |
| Vasoactive medication | ||||
| No | 16 338 (88.2) | 16 053 (88.2) | 285 (86.4) | .30 |
| Yes | 2189 (11.8) | 2144 (11.8) | 45 (13.6) | |
| Not reported | 988 (5.1) | 967 (5.0) | 21 (6.0) | |
| Vasoactive medication–free days among ICU-admitted patients, median (IQR) | 28 (26-29) | 28 (26-29) | 28 (25-29) | .10 |
| Sepsis days, median (IQR) | 5 (3-9) | 5 (3-9) | 5 (3-8) | .67 |
| Placement of central venous line | ||||
| No | 11 255 (87.0) | 11 052 (87.1) | 203 (81.5) | .01 |
| Yes | 1676 (13.0) | 1630 (12.9) | 46 (18.5) | |
| Not reported | 6584 (33.7) | 6482 (33.8) | 102 (29.1) | |
Abbreviation: ICU, intensive care unit.
a
Statistical significance was set at 2-sided P < .05.