Figure 9.

Determining nanoparticle stability using the the fraction of polar surface area predicted from two-dimensional properties ( ${\mathrm{FASA}}_{\mathrm{p}}^{\mathrm{pred}}$ ). (A) ${\mathrm{FASA}}_{\mathrm{p}}^{\mathrm{pred}}$ plotted against the minimum weight percentage of excipient needed to form a stable nanosuspension (min wt.%). The Pearson correlation coefficient ( $\rho$ ) between ${\mathrm{FASA}}_{\mathrm{p}}^{\mathrm{pred}}$ and min wt.% is also shown. (B) Using ${\mathrm{FASA}}_{\mathrm{p}}^{\mathrm{pred}}$ to predict the probability that a stable nanosuspension is formed ( $P_s$ ) using a logistic regression. True data (orange dots) and the resulting fit (blue line) are both shown.