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Diagram depicting molecular interactions in cisplatin-resistant tumor cells. FRα stabilizes MDM2, which interacts with TP53. TP53 activation leads to the activation of p21, which in turn inhibits FAS-mediated apoptosis, rendering the tumor cell unable to undergo apoptosis on exposure to cisplatin. Cisplatin, especially in cisplatin-resistant tumor cells, is associated with higher p21 levels via its interaction with TP53, which in turn inhibit FAS-mediated apoptosis.
