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. 2024 May 8;103(7):103841. doi: 10.1016/j.psj.2024.103841

Figure 2.

Figure 2

CircRAB11A promoted proliferation and inhibited apoptosis of GCs. (A, B) After transfection with circRAB11A interference or overexpression vector, the mRNA levels of CCND1, CCND2, CDK2, and PCNA were assessed by qPCR. n = 9. (C, D) After transfection with circRAB11A interference or overexpression vector, the growth curve of GCs was evaluated by CCK-8 reagent. n = 8. (E, F) The proliferation status of GCs determined by EdU assay after transfection of circRAB11A. n=3. (G, H) After transfection with circRAB11A interference or overexpression vector, the mRNA levels of BCL2, Caspase3, Caspase8 and Caspase9 were assessed by qPCR. n = 9. (I, J) The apoptosis state of GCs determined by TUNEL assay after transfection of circRAB11A. n = 3. (K) After transfection with circRAB11A interference or overexpression vector, the protein level of β-tubulin, Caspase9 was assessed by western blot. n = 3. Values represent mean ± SEM. * P < 0.05 and ⁎⁎P < 0.01.