Table 1.
Methylation levels of candidate DMRs according to the sarcopenic status in the validation sets
| DMRs | Non‐sarcopenia | Sarcopenia | P | Moderate sarcopenia | Severe sarcopenia | P |
|---|---|---|---|---|---|---|
| CTSB_15 a | 0.19 (0.13, 0.27) | 0.13 (0.09, 0.19) | <0.001 | 0.14 (0.09, 0.19) | 0.13 (0.09, 0.19) | 0.125 |
| CTSB_17 a | 0.54 (0.49, 0.61) | 0.58 (0.53, 0.62) | <0.001 | 0.59 (0.52, 0.61) | 0.58 (0.53, 0.62) | 0.509 |
| CXCL12_22 a | 0.73 (0.64, 0.78) | 0.64 (0.54, 0.72) | <0.001 | 0.61 (0.48, 0.68) | 0.67 (0.57, 0.76) | <0.001 |
| FGF19_28 a | 0.29 (0.24, 0.34) | 0.33 (0.26, 0.40) | <0.001 | 0.33 (0.25, 0.39) | 0.33 (0.27, 0.41) | 0.253 |
| FGF21_59 a | 0.07 (0.04, 0.15) | 0.07 (0.03, 0.12) | 0.367 | 0.05 (0.02, 0.09) | 0.08 (0.04, 0.13) | <0.001 |
| FGF2_30 a | 0.20 (0.12, 0.27) | 0.06 (0.03, 0.10) | <0.001 | 0.07 (0.04, 0.12) | 0.05 (0.03, 0.09) | <0.001 |
| SESN1_48 a | 0.76 (0.71, 0.81) | 0.76 (0.64, 0.82) | 0.414 | 0.76 (0.71, 0.81) | 0.76 (0.45, 0.83) | 0.070 |
| FGF2_30 b | 0.19 (0.13, 0.26) | 0.13 (0.09, 0.16) | <0.001 | 0.14 (0.09, 0.19) | 0.11 (0.09, 0.15) | 0.003 |
DMRs, differentially methylated regions.
a
Data from Validation set 1.
b
Data from Validation set 2.