Table 2.
Mediating role of frailty in systemic inflammation and osteoporosis/fracture risk association
| Outcome | Systemic inflammation markers | HR (95% CI) | Proportion of mediation | ||
|---|---|---|---|---|---|
| Total effect | Direct effect | Indirect effect | |||
| OP | SII | 1.105 (1.085, 1.125) | 1.096 (1.077, 1.116) | 1.0074 (1.0065, 1.008) | 7.39% (6.53%, 8.30%) |
| NLR | 1.090 (1.070, 1.110) | 1.084 (1.064, 1.104) | 1.006 (1.005, 1.007) | 6.65% (5.75%, 7.59%) | |
| PLR | 1.085 (1.066, 1.105) | 1.083 (1.064, 1.103) | 1.002 (1.001, 1.003) | 2.21% (1.41%, 3.03%) | |
| Fracture | SII | 1.065 (1.049, 1.081) | 1.062 (1.046, 1.078) | 1.003 (1.002, 1.004) | 4.68% (3.78%, 5.63%) |
| NLR | 1.057 (1.041, 1.073) | 1.054 (1.039, 1.070) | 1.002 (1.002, 1.003) | 4.19% (3.35%, 5.09%) | |
| PLR | 1.072 (1.056, 1.088) | 1.071 (1.055, 1.087) | 1.001 (1.000, 1.001) | 1.03% (0.62%, 1.47%) | |
Note: Models were adjusted for age, sex, ethnicity, body mass index, annual household income, Townsend deprivation index, education level, drinking status, smoking status and nutrient and mineral supplementation. Abbreviations: CI, confidence interval; HR, hazard ratio; NLR, neutrophil‐to‐lymphocyte ratio; OP, osteoporosis; PLR, platelet‐to‐lymphocyte ratio; SII, systemic immune‐inflammation index.