FIGURE 8.

DCTN2 accelerated HCC progression by activating AKT pathway. (A, B) Knockdown DCTN2 suppressed AKT phosphorylation, while this was partial reversed by SC‐79, an AKT pathway activator. (C) CCK‐8 assay demonstrated that the inhibitory ability to HCC cells proliferation after DCTN2 silence was counteracted by SC‐79. (D, E) Transwell invasion assay demonstrated that the inhibitory ability to HCC cells metastasis after DCTN2 silence was counteracted by SC‐79. **p < 0.01, ***p < 0.001, ****p < 0.0001; NS, not significant.