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. Author manuscript; available in PMC: 2024 Jun 6.
Published in final edited form as: Resuscitation. 2023 Feb 16;186:109735. doi: 10.1016/j.resuscitation.2023.109735

Figure 2: Rate of ROSC and Post-ROSC Survival in Swine Resuscitated with T3np, T3np+PCR, and EPI After Cardiac Arrest.

Figure 2:

(A) Compared with vehicle treatment, EPI, T3np, and T3np+PCr administration during CPR resulted in a significant improvement in the rate of ROSC that was not different between treatment groups. The time needed to achieve ROSC was also similar among treatment groups. (B) The timecourse of post-ROSC survival among each group (left panel) reveals a similar pattern among EPI-, T3np-, and T3np+PCR-treated animals such that a majority of animals died prior to the 4-hour post-ROSC timepoint. Overall, average post-ROSC survival duration did not differ among treatment groups (right panel). Values are mean±SEM. *p<0.05 vs. empty NP; †p=0.08 vs. empty NP. ROSC = return of spontaneous circulation; NP = nanoparticles; T3np = triiodothyronine nanoparticles; T3np+PCr = triiodothyronine nanoparticles with encapsulated phosphocreatine.