Table 6. Stability at LQC and HQC Levels of DEM and DEX in Rat Plasma (n = 6).

stability	analyte	nominal conc. (ng/mL)	calculated conc. (ng/mL)	precision (% CV)	% difference
benchtop stability (19 h and 28 min)	DEM	0.58	0.59 ± 0.05	8.47	5.29
		302.52	300.16 ± 11.76	3.92	–0.36
	DEX	0.30	0.29 ± 0.02	6.9	0.00
		156.76	153.91 ± 5.91	3.84	–0.70
wet extract stability (42 h and 12 min)	DEM	0.58	0.61 ± 0.05	8.20	8.86
		302.52	298.73 ± 10.53	3.52	–0.83
	DEX	0.30	0.31 ± 0.02	6.45	6.90
		156.76	153.92 ± 5.87	3.81	–0.69
processed sample stability (28 h and 21 min)	DEM	0.58	0.56 ± 0.03	5.36	–0.06
		302.52	308.31 ± 8.23	2.67	2.35
	DEX	0.30	0.030 ± 0.01	3.33	3.45
		156.76	151.91 ± 3.03	1.99	–1.99
freeze thaw stability (five cycles)	DEM	0.58	0.57 ± 0.03	5.26	1.72
		302.52	293.62 ± 16.24	5.53	–2.53
	DEX	0.30	0.30 ± 0.02	6.67	3.45
		156.76	156.02 ± 1.22	0.78	0.66
autosampler stability (64 h and 3 min)	DEM	0.58	0.58 ± 0.03	5.17	3.51
		302.52	308.23 ± 7.69	2.49	2.32
	DEX	0.30	0.28 ± 0.02	7.14	–3.45
		156.76	149.71 ± 5.67	3.79	–3.41
long-term stability (49 days)	DEM	0.58	0.58 ± 0.03	5.17	3.51
		302.52	299.62 ± 9.41	3.14	–0.54
	DEX	0.30	0.30 ± 0.02	6.67	3.45
		156.76	155.49 ± 7.51	4.83	0.32