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. 2024 Jun 5;24:687. doi: 10.1186/s12885-024-12452-x

Table 2.

The sensitivity and specificity of SHOX2 and RASSF1A methylation in diagnosing lung adenocarcinoma

Methylation indexes Cutoff Sensitivity for IA Sensitivity for MIA Sensitivity for AIS Specificity for BC
SHOX2 8.3 55.0% (94/171) 30.6% (11/36) 9.7%(3/31) 97.1% (33/34)
RASSF1A 12 50.3% (86/171) 22.2% (8/36) 12.9%(4/31) 97.1% (33/34)
LungMe® - 71.3% (122/171) 41.7% (15/36) 16.1%(5/31) 94.1% (32/34)

Note LungMe® is a combination of SHOX2 and RASSF1A methylation

MIA: microinvasive adenocarcinoma; IA: invasive adenocarcinoma