Table 1b.
Descriptive characteristics of additional emerging cohorts with potential to contribute to the I4C data pool.
| Country/ Recruiting years |
Study title (Acronym) |
Sample size |
Recruitment
period |
Pre-natal follow-up time points (weeks gestation) |
Age at Post-natal follow- up time points |
Method/s of follow-up |
Method/s of pediatric cancer ascertainment |
|
|---|---|---|---|---|---|---|---|---|
| GROUP A: Cohorts that are well established, collecting relevant data/biospecimens, able to ascertain cases of CC and are positioned to begin contributing data to the I4C pool within the next few years. | ||||||||
|
China* 2012-2017 |
Born in Guangzhou Cohort Study (BIGCS) | 30,000 | Early pregnancy | ■ 20 ■ 24-28 ■ ≥ 33 ■ Birth |
■ 6 weeks ■ 6,12,36 months ■ 3, 6, 10, 12-13, 15-16, 18 years |
■ Self-administered questionnaires ■ Clinical assessments |
Guangzhou Cancer Registry | |
|
France* 2011 |
Etude Longitudinale Française depuis l'enfance (ELFE) | 18,300 | Birth | n/a | ■ 2 months ■ 1,2,3,5 years |
■ Face-to-face and phone interviews ■ Clinical assessments |
National Childhood Cancer Registry and National Health Insurance | |
|
Italy* 2005-2016 |
Nascita ed Infanzia: gli Effetti dell’Ambiente (NINFEA) | 7,500 | Any time during pregnancy | n/a | ■ 6 months ■ 18 months ■ 4, 7, 10 years (planned at 13, 16 years) |
On-line self-administered questionnaires | Population-based regional cancer registry and nationwide clinical registry | |
|
Japan* 2011-2014 |
Japan Environment and Children’s Study (JECS) | 100,000 | Early pregnancy | ■ First trimester ■ 2nd- 3rd trimester ■ Birth |
■ 1, 6, 12 months ■ Every 6 months to age 13 years |
Self-administered questionnaires | Physician completed questionnaire based on WHO cancer classification | |
|
Korea* 2015 -2019 |
Korean Children’s Environmental Health Study (Ko-CHENS) | 70,000 | Early pregnancy | ■ First trimester ■ 3rd trimester |
■ 6 months ■ 1 year ■ 2 years ■ 3 years ■ up to 18 years |
Self-administered questionnaires | National Health Insurance Service | |
| Sub-total | 225,800 | |||||||
| GROUP B: Cohorts currently in various stages of development or early recruitment and follow-up, are collecting or plan to collect relevant data/biospecimens and identify cases of CC that have the potential to contribute data to the I4C pool in the future. | ||||||||
| Australia* Planned 2020 - 2022 | Generation Victoria (GenV) | Estimated 160,000 | Birth | ■ Trimester 1, 2, 3 | ■ To be determined | ■ Administrative data linkage ■ Clinical data records |
Proposed linkage to state and national cancer registries | |
| Brazil* 2014+ | Campinas Infant Health Study | 100,000 | Early pregnancy | ■ 12 ■ 30 ■ Birth |
■ 6 months ■ 18 months … to 18 years |
Electronic, self-administered questionnaires | Linkage to Primary Care Units | |
| China* 2010 - 2013 | Wuhan Study | 120,000 | Early pregnancy | ■ <12 weeks | ■6 weeks | ■ Questionnaires administered during home visits ■ Clinical examinations ■ Electronic health records ■ Monitoring |
Wuhan Cancer Registry | |
| Taiwan 2013 - 2010 | Taiwan Birth Cohort Study (TBCS) | 20,000 | Birth | n/a | ■ 6 months ■ 18 months ■ 3 years ■ 5 years |
■ Self-reported questionnaires | To be determined | |
| Sub-total | 400,000 | |||||||
| TOTAL | 627,500 | |||||||
*
Cohorts with prospectively collected biological samples