Extended Data Fig. 6. Masked IL-12 reduces organ damage in MC38-bearing mice.
Mice bearing day 7 MC38 tumors were treated i.v. with either PBS (n = 6), IL-12 (83.3 pmol, n = 7) or M-L6-IL12 (250 pmol, n = 6) on days 7, 10 and 13. Plasma was collected on day 16 and levels of ALT (a), AST (b), amylase (c) and total protein (d) were quantified using a blood chemistry analyzer. Data are mean ± s.e.m. Statistical analyses were performed using ordinary one-way ANOVA with Tukey’s multiple comparison test. Experiments were performed twice with similar results.