Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Amino acid sequences of linkers used to generate masked IL-12 variants.
| Linker ID | Amino acid sequence | Cleaved by |
|---|---|---|
| L1 | (GGGS)2(HPVGLLAR)3(GGGS)2 | MMP2, MMP9 |
| L2 | (GGGS)2(SGLLSGRSDNH)3(GGGS)2 | uPA, matriptase, legumain |
| L3 | (GGGS)2(VPLSLYSG)3(GGGS)2 | MMP2, MMP7, MMP9 |
| L4 | (GGGS)2(VPLSLYSG)(GGGS)2(LSGRSDNH)2(GGGS)2 | MMP and Serine Proteases |
| L6 | (HPVGLLARVPLSLYSG)2(LSGRSDNH)(GGGS)2 | MMP and Serine Proteases |
| LNC | (GGGS)11 | Non-cleavable |
Linker substrates are shown in bold font.
